Cialis daily could help men with ED return to normal erectile function

Cialis dailyThe results of a new study published in the Journal of Sexual Medicine show that men with an ‘incomplete response’ to an as-needed PDE5 inhibitor treatment for impotence, achieved normal erectile function after taking a course of Cialis (Tadalafil) once daily treatment – via measurement on the erectile function domain of the International Index of Erectile Function (IIEF-EF). This is a series of questions used as a measure for efficacy assessment in erectile dysfunction clinical trials, first developed in conjunction with the clinical trial program for sildenafil.

Cialis belongs to a class of drugs known as a ‘Phosphodiesterase-5 (PDE-5) inhibitor’, first approved to treat erectile dysfunction (ED) and then for the signs and symptoms of benign prostatic hyperplasia (BPH).

“PDE5 inhibitors are highly effective for most men when taken as-needed, but responses can range from minimal change to a return to normal erectile function,” said Dr Edward D. Kim, MD, of the Division of Urology, Department of Surgery, University of Tennessee Graduate School of Medicine and lead author of the study. “We believe the study outcome will help prescribers make better informed decisions when treating their patients.”

The study was a randomised, double-blind, parallel, placebo-controlled trial that encompassed 51 sites from the United States and Canada. Participants in the study were men 18-years-old or over who had taken an as-need PDE5 inhibitor at maximum dose and achieved some response to the treatment (IIEF-EF >/= 17), however had not managed to experience a normal erectile function (IIEF-EF <26).

Researchers analysed the superiority of the Cialis daily treatment to that of a placebo in helping the men get back to a normal erectile function. There were a total of 623 subjects randomly assigned to receive Cialis as a once daily treatment, or given the ineffective placebo.

A primary objective of the study was to determine if a significantly greater percentage of the men returned to normal erectile function when given Cialis 2.5 titrated to 5 mg and 5 mg once daily, in comparison to a placebo.

Treatment with the Cialis daily in this matter met the primary objective with significantly higher percentages of men (38.7 percent and 39.6 percent, respectively) with IIEF-EF domain scores in the normal range (>/= 26) through 12 weeks versus the placebo (12.1 percent; both, p<.001).

By the fourth week of assessment, significantly higher percentages of men taking the Cialis 2.5 to 5 mg and 5 mg (33.5 percent and 41.1 percent, respectively) had successfully returned to normal erectile function (placebo, 8.5 percent; both, p<.001).

The study highlights the prowess of Cialis daily for the treatment of erectile dysfunction. Cialis vs Viagra  is a difficult choice for many, but it is worth bearing in mind that the lower strength versions of Cialis are particularly ideally for men in sexually active long-term relationships. Beneficial in that the mild dose will be in your body each day, it means you do not have to take a tablet each time you have sex. Your body should begin to adjust to the medication’s ingredients and resulting in very little side effects, if any.

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